Flu season hits early and, in some places, hard


NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers have limited visitors, and one Pennsylvania hospital set up a tent outside its ER to handle the feverish patients.


Flu season in the U.S. has hit early and, in some places, hard. But whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.


"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.


The evidence so far is pointing to a moderate season, Schaffner and others believe. It just looks bad compared with last year — an unusually mild one.


Flu usually doesn't blanket the country until late January or February, but it is already widespread in more than 40 states.


What's probably complicating the situation: The main influenza virus this year tends to make people sicker. And there are other bugs out there causing flu-like illnesses. So what people are calling the flu may, in fact, be something else.


"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.


The flu's early arrival in the U.S. coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes what some people call "stomach flu."


Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it's sometimes hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.


Flu is a major contributor, though, to what's going on.


"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed ER saw its busiest day ever last week, with 166 visitors.


The early onslaught has resulted in a spike in hospitalizations, prompting hospitals to take steps to deal with the influx and protect other patients from getting sick, including restricting visits from children, requiring family members to wear masks, and banning anyone with flu symptoms from maternity wards.


One hospital in Allentown, Pa., this week set up a tent for a steady stream of patients with flu symptoms.


But so far, "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.


On Wednesday, Boston declared a public health emergency, and all the flu activity has caused some to question whether this year's flu shot is working.


There's a new flu vaccine each year, based on the best guess of what flu viruses will be strongest that year. This year's vaccine is well-matched to what's going around. The government estimates that between a third and a half of Americans have gotten the vaccine.


But the vaccine isn't foolproof, and even those who were vaccinated can still get sick. At best, the vaccine may be only 75 percent effective in younger people and even less so in the elderly and people with weak immune systems.


Health officials are analyzing the vaccine's effectiveness, but early indications are that about 60 percent of all vaccinated people have been protected from the flu. That's in line with how effective flu vaccines have been in other years.


In New York City, 57-year-old Judith Quinones suffered her worst case of flu-like illness in years, laid up for nearly a month with fever and body aches. "I just couldn't function," she said.


She decided to skip getting a flu shot last fall. But her daughter got the shot. "And she got sick twice," Quinones said.


On average, about 24,000 Americans die each flu season, according to the CDC.


Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.


Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.


The last bad flu season involved a swine flu that hit in two waves in the spring and fall of 2009. But that was considered a unique strain, different from the regular winter flu.


___


Online:


CDC flu: http://www.cdc.gov/flu/index.htm


Read More..

Source: Britney Spears out of 'X Factor'


LOS ANGELES (AP) — A person familiar with plans for Fox's "The X Factor" says Britney Spears is out of the show.


Spears was a mentor on the singing contest for one season, reportedly drawing a $15 million paycheck but failing to pull reviews to match. The person who confirmed reports of her departure wasn't authorized to comment publicly, speaking Thursday on condition of anonymity.


The person said that over the holidays, producers discussed replacements for Spears and for another "X Factor" panelist, record executive Antonio "L.A." Reid. Reid previously announced he would leave the show after two seasons.


It's yet another shake-up for "The X Factor," Simon Cowell's attempt to strike magic with a U.S. version of his successful U.K. series. Cowell replaced panelists Paula Abdul and Nicole Scherzinger after a disappointing first season.


Read More..

Jewel-Osco stores to be sold to Cerberus group

Jewel-Osco stores will be sold to a consortium of investors led by Cerberus Capital Management, Jewel's parent Supervalu said today. (WGN - Chicago)









Jewel-Osco stores will be sold to a consortium of investors led by Cerberus Capital Management, Jewel's parent Supervalu said Thursday.

The deal, valued at $3.3 billion, also includes the Albertsons, Acme, and Shaw stores.






The announcement ends months of speculation that all or parts of the troubled grocery chain would be sold to New York-based Cerberus, an investment firm. Supervalu acquired Jewel in 2006 as part of a larger, complex acquisition of the Albertsons company.

Supervalu also reported earnings of $16 million, or 8 cents per share, in the third quarter ended on Dec. 1, compared with a year-earlier loss of $750 million, or $3.54 per share.

Excluding an after-tax gain related to a cash settlement from credit card companies and after-tax charges primarily related to store closures, it earned $5 million, or 3 cents per share.

As part of the deal, which includes $100 million in cash and $3.2 billion in debt, the five grocery chains will be acquired by AB Acquisition, an affiliate of Cerberus. Other investors in the deal include Kimco Realty Corp, Klaff Realty, Lubert-Adler Partners and Schottenstein Real Estate Group.

Following the sale, which is expected to close in the spring, a newly formed entity called Symphony Investors, led by Cerberus, will purchase up to 30 percent of Supervalu's outstanding shares for $4 each, representing a 50 percent premium over the stock's 30-day average. If Symphony cannot acquire at least 19.9 percent of the outstanding shares at that price, Supervalu must issue additional stock.

Wall Street has long expected Eden Prairie, Minn.-based Supervalu to sell some or all of its assets.

Following the deal, Supervalu will consist of its wholesale grocery business, the Save-A-Lot discount chain, and traditional grocery chains like Cub, Shop N' Save and Hornbacher's.

In a call with investors, outgoing CEO Wayne Sales said the deal brings Supervalu "a very strong balance sheet," and the ability to focus on investments in price reductions, fresh produce, and customer experience at its remaining chains. 

The new company is smaller, "with more bandwidth and leadership" to focus on its wholesale business, Save-A-Lot, and its traditional grocery stores, he said.

Sam Duncan, 61, will replace Wayne Sales as CEO. Duncan was CEO of Office Max from 2005 to 2011, and prior to that, was CEO of ShopKo, a Midwestern grocery chain. Five unidentified board members will resign as part of the deal, making room for Duncan, Albertsons CEO Robert Miller, and three new appointees. The size of the board will shrink from 10 to seven.

Concurrent with the announcement, Supervalu announced that it has secured access to a $900 million asset-based credit facility, and a $1.5 billion loan.

This deal ends a long and difficult year for one of the country's largest grocers.

Last April, Supervalu reported a loss of $1.04 billion for fiscal 2012, which included a $519 million operating loss and $509 million in interest expense. Sales also declined 3 percent, to $27.9 billion. In July, the company said it was exploring strategic alternatives, including a sale. Soon after, the company dismissed CEO Craig Herkert, with Chairman Wayne Sales stepping in to helm the troubled grocer.

Cerberus, an investor in the deal to acquire Albertsons in 2006 was long seen as the leading candidate. Last week, rumors that Supervalu was near a deal with Cerberus sent stock soaring nearly 15 percent.

In September, Supervalu said it would 60 underperforming stores, primarily from the Save-A-Lot and Albertsons chains. No Jewel locations were identified at the time. The announcement was particularly troubling to investment community because Save-A-Lot, a hard discount chain, has been Supervalu's primary growth vehicle.

Supervalu has long acknowledged that many of its stores are not price competitive. In 2012, it homed in on Jewel-Osco and the Chicago market. Supervalu surveyed customers and lowered prices throughout the store. When the company reported results for its second fiscal quarter in September, (Supervalu CEO Wayne) Sales said that Jewel had been "competitively priced throughout the store" for about six weeks.

Sales said that the initiative had resulted in "dramatic improvement" in how consumers "think about the quality of products we sell, how they feel about the service they get in various departments" and that the company was pleased with increased unit sales.

Read More..

More turbulence for Dreamliner









Chicago-based Boeing Co. has "extreme confidence" in its new and highly trumpeted  787 Dreamliner, and the plane is safe, Mike Sinnett, the chief project engineer for the 787 said during a news conference Wednesday.

The public statements came on the third day in a row that different Boeing 787s sustained high-profile problems, including an electrical battery fire on Monday, a fuel leak on Tuesday and a reported problem with the braking system on Wednesday.






"Clearly, there are issues," Sinnett said, adding that he won't be happy until the Dreamliner is completely reliable. However, all new planes have such "teething pains," and the 787 problems are similar to incidents experienced when the Boeing 777 went into service, he said.

"Just like any new airplane program, we work through those issues and we move on," he said. "I am 100 percent convinced that the airplane is safe to fly. I fly on it myself all the time."

Aviation experts, industry analysts and some Boeing customers have echoed that, saying that all new aircraft have such problems for the first year or two and that such glitches don't make flying in a 787 unsafe.

The first 787 Dreamliner was delivered 15 months ago -- more than three years late because of design and production delays -- to a Japanese airline, and there are now 50 Dreamliners in service with various airlines around the world.

Chicago-based United Airlines has six 787s. Since early November, the airline has been flying a temporary 787 route between Chicago O'Hare and Houston, as well as on other domestic routes. The Chicago route is scheduled to end March 29, when United will move the 787s to international routes. United conducted a special inspection of its 787s after an electrical fire occurred on a Japanese Dreamliner on Monday, but United has not released results of that inspection.

LOT Polish Airlines will operate the first regular 787 route out of O'Hare -- to Warsaw -- starting with an inaugural flight scheduled for next week.

The Dreamliner is touted as offering greater passenger comforts and better fuel efficiency than any other airplane in its class, largely due to far more use of light composite materials rather than metals.

However, it has seen its share of problems, including a rash of incidents recently.

Japan's All Nippon Airways said Wednesday that it was forced to cancel a 787 Dreamliner flight scheduled from Yamaguchi prefecture in western Japan to Tokyo due to brake problems. That followed a fuel leak on Tuesday that forced a 787 operated by Japan Airlines to cancel takeoff at Boston's Logan International Airport, a day after an electrical fire on another 787 after a Japan Airlines flight to Boston from Tokyo.

Last month, the Federal Aviation Administration ordered inspections on 787s for a problem with fuel leaks.

In a news conference Wednesday dominated by technical discussions of the 787's electrical systems and batteries, Sinnett emphasized the "redundancies" or backup protections built into the aircraft's electrical systems. For example, the plane has six power generators but can fly with just one functioning, he said.

The 787 more heavily relies on electrical components than any other aircraft, in an effort to shed the weight of traditional pneumatic systems and improve fuel efficiency, he said.

Overall, the plane is meeting goals for fuel efficiency and passenger comfort, Sinnett said. "We're very, very happy with how the airplane is performing," he said.

Asian customers rallied behind the Boeing, saying such troubles were not uncommon on new planes and confirming they had no plans to scale back or cancel orders for the aircraft, which has a list price of $207 million.

Japan is by far the biggest customer for the Dreamliner to date, with JAL and All Nippon Airways (ANA) operating a total of 24 of the 49 new planes delivered to end-December. The aircraft entered commercial service in November 2011, more than three years behind schedule after a series of production delays. Boeing has sold 848 of the planes.

JAL spokesman Kazunori Kidosaki said the carrier, which operates seven Dreamliners, had no plans to change orders it has placed for another 38 aircraft. ANA, which has 17 Dreamliners flying its colors, will also stick with its orders for another 49, spokesman Etsuya Uchiyama said.

State-owned Air India, which on Monday took delivery of the sixth of the 27 Dreamliners it has ordered, said precautionary measures were already in place and its planes were flying smoothly.

"It's a new plane, and some minor glitches do happen. It's not a cause of concern," said spokesman G. Prasada Rao. There was no immediate suggestion that the 787 Dreamliner, the world's first passenger jet built mainly from carbon-plastic lightweight materials to save fuel, was likely to be grounded as investigators looked into the fire incident.

Air China, which sees the 787 as a way to expand its international routes, and Hainan Airlines also said they were keeping their orders for 15 and 10 of the planes.

"New airplanes more or less will need adjustments, and currently we have no plans to swap or cancel orders," said an executive at future 787 operator Hainan Airlines, who was not authorized to talk to the media and did not want to be named.

Qatar Airways Chief Executive Akbar Al Baker, who has previously criticized technical problems or delays with Boeing or Airbus jets, said there were no technical problems with the five 787s currently in use by the Gulf carrier. "It doesn't mean we are going to cancel our orders. It's a revolutionary airplane," he said.

gkarp@tribune.com

Reuters contributed

Read More..

Google drops key patent claims against Microsoft


WASHINGTON (Reuters) - Google unit Motorola Mobility has asked a trade panel to drop two key patents from an infringement complaint that it filed against Microsoft, according to a filing at the International Trade Commission.


The ITC has been considering accusations by Motorola Mobility, which has since been purchased by Google, that Microsoft infringed on its patented technology to make its popular Xbox.


Google filed a motion with the ITC on Tuesday, asking that two patents be withdrawn from the case. One patent remains, according to the filing.


The withdrawal was required under an agreement that Google made with the Federal Trade Commission last week settling a pair of long-running antitrust investigations.


The FTC, U.S. Department of Justice and U.S. Patent and Trademark Office assert that companies should not request sales bans when filing patent infringement lawsuits based on patents that are essential to a standard in most cases. Standard essential patents ensure that devices are interoperable.


Microsoft identified the two patents withdrawn from the ITC case as standard essential patents.


"We're pleased that Google has finally withdrawn these claims for exclusion orders (sales bans) against Microsoft, and hope that it will now withdraw similar claims pending in other jurisdictions," David Howard, Microsoft's deputy general counsel, said in an emailed statement.


Google did not immediately respond to requests for a comment.


Microsoft said that standard essential patents had been asserted in cases in Wisconsin and Washington district courts, both of which have been stayed. Sales bans, or injunctions, were requested in both cases, Microsoft said.


The ITC is a popular venue for patent lawsuits because it can bar the importation of infringing products and because it issues decisions relatively quickly.


The International Trade Commission case is No. 337-752.


(Reporting By Diane Bartz; Editing by Maureen Bavdek)



Read More..

Bonds, Clemens rejected; no one elected to BB Hall


NEW YORK (AP) — Steroid-tainted stars Barry Bonds, Roger Clemens and Sammy Sosa were denied entry to baseball's Hall of Fame, with voters failing to elect any candidates for only the second time in four decades.


In a vote that keeps the game's career home run leader and one of its greatest pitchers out of Cooperstown — at least for now — Bonds received just 36.2 percent of the vote and Clemens 37.6 in totals announced Wednesday by the Hall and the Baseball Writers' Association of America, both well short of the 75 percent necessary. Sosa, eighth on the career home run list, got 12.5 percent.


"Curt Schilling made a good point, everyone was guilty. Either you used PEDs, or you did nothing to stop their use," Hall of Famer Mike Schmidt said in an email to The Associated Press. "This generation got rich. Seems there was a price to pay."


Bonds, Clemens and Sosa were eligible for the first time and have up to 14 more years on the writers' ballot to gain baseball's highest honor.


"After what has been written and said over the last few years I'm not overly surprised," Clemens said in a statement he posted on Twitter.


Craig Biggio, 20th on the career list with 3,060 hits, topped the 37 candidates with 68.2 percent of the 569 ballots, 39 shy of election. Among other first-year eligibles, Mike Piazza received 57.8 percent and Schilling 38.8.


Jack Morris led holdovers with 67.7 percent. He will make his final ballot appearance next year, when fellow pitchers Greg Maddux and Tom Glavine along with slugger Frank Thomas are eligible for the first time.


Two-time NL MVP Dale Murphy received 18.6 percent in his 15th and final appearance.


"With 53 percent you can get to the White House, but you can't get to Cooperstown," BBWAA secretary-treasurer Jack O'Connell said. "It's the 75 percent that makes it difficult."


It was the eighth time the BBWAA failed to elect any players. There were four fewer votes than last year and five members submitted blank ballots.


"It's a tough period for evaluation, that's what this chalks up to," Hall President Jeff Idelson said. "Honestly, I think that any group you put this to would have the same issues. ... There's always going to be discussion and concern about players who didn't get in, but at the end of the day it's a process and again, a snapshot in time isn't one year, it's 15 with this exercise."


Bonds, baseball's only seven-time Most Valuable Player, hit 762 home runs, including a record 73 in 2001.


"It is unimaginable that the best player to ever play the game would not be a unanimous first-ballot selection," said Jeff Borris of the Beverly Hills Sports Council, Bonds' longtime agent.


Clemens, the only seven-time Cy Young Award winner, is third in career strikeouts and ninth in wins.


"To those who did take the time to look at the facts," Clemens said, "we very much appreciate it."


Since 1961, the only years the writers didn't elect a candidate were when Yogi Berra topped the 1971 vote by appearing on 67 percent of the ballots cast and when Phil Niekro headed the 1996 ballot at 68 percent. Both were chosen the following years when they achieved the 75 percent necessary for election.


The other BBWAA elections without a winner were in 1945, 1946, 1950, 1958 and 1960.


"Next year, I think you'll have a rather large class and this year, for whatever reasons, you had a couple of guys come really close," Commissioner Bud Selig said at the owners' meetings in Paradise Valley, Ariz. "This is not to be voted to make sure that somebody gets in every year. It's to be voted on to make sure that they're deserving. I respect the writers as well as the Hall itself. This idea that this somehow diminishes the Hall of baseball is just ridiculous in my opinion."


Players' union head Michael Weiner called the vote "unfortunate, if not sad."


"To ignore the historic accomplishments of Barry Bonds and Roger Clemens, for example, is hard to justify. Moreover, to penalize players exonerated in legal proceedings — and others never even implicated — is simply unfair. The Hall of Fame is supposed to be for the best players to have ever played the game. Several such players were denied access to the Hall today. Hopefully this will be rectified by future voting."


Three inductees were chosen last month by the 16-member panel considering individuals from the era before integration in 1947: Yankees owner Jacob Ruppert, umpire Hank O'Day and barehanded catcher Deacon White. They will be enshrined during a ceremony in Cooperstown on July 28, when the Hall also will honor Lou Gehrig and Rogers Hornsby among a dozen players who never received formal inductions because of restrictions during World War II.


Bonds has denied knowingly using performance-enhancing drugs and was convicted of one count of obstruction of justice for giving an evasive answer in 2003 to a grand jury investigating PEDs. Clemens was acquitted of perjury charges stemming from congressional testimony during which he denied using PEDs.


Sosa, who finished with 609 home runs, was among those who tested positive in MLB's 2003 anonymous survey, The New York Times reported in 2009. He told a congressional committee in 2005 that he never took illegal performance-enhancing drugs.


The BBWAA election rules say "voting shall be based upon the player's record, playing ability, integrity, sportsmanship, character, and contributions to the team(s) on which the player played."


An Associated Press survey of 112 eligible voters conducted in late November after the ballot was announced indicated Bonds, Clemens and Sosa would fall well short of 50 percent. The big three drew even less support than that as the debate raged over who was Hall worthy.


Voters are writers who have been members of the BBWAA for 10 consecutive years at any point.


BBWAA president Susan Slusser of the San Francisco Chronicle said she didn't vote for Bonds, Clemens or Sosa.


"The evidence for steroid use is too strong," she said.


As for Biggio, "I'm surprised he didn't get in."


MLB.com's Hal Bodley, the former baseball columnist for USA Today, said Biggio and others paid the price for other players using PEDs.


"They got caught in the undertow of the steroids thing," he said.


Bodley said this BBWAA vote was a "loud and clear" message on the steroids issue. He said he couldn't envision himself voting for stars linked to drugs.


"We've a forgiving society, I know that," he said. "But I have too great a passion for the sport."


Mark McGwire, 10th on the career home run list, received 16.9 percent on his seventh try, down from 19.5 last year. He received 23.7 percent in 2010 — a vote before he admitted using steroids and human growth hormone.


Rafael Palmeiro, among just four players with 500 homers and 3,000 hits along with Hank Aaron, Willie Mays and Eddie Murray, received 8.8 percent in his third try, down from 12.6 percent last year. Palmeiro received a 10-day suspension in 2005 for a positive test for performance-enhancing drugs, claiming it was due to a vitamin vial given to him by teammate Miguel Tejada.


While there are exhibits about the Steroids Era at the Hall, the plaque room will remain without Bonds and Clemens, who join career hits leader Pete Rose on the outside looking in. There were four write-in votes for Rose, who never appeared on the ballot because of his lifetime ban that followed an investigation of his gambling while manager of the Cincinnati Reds.


Morris increased slightly from his 66.7 percent last year, when Barry Larkin was elected. Morris could become the player with the highest-percentage of the vote who is not in the Hall, a mark currently held by Gil Hodges at 63 percent in 1983.


Several players who fell just short in the BBWAA balloting later were elected by either the Veterans Committee or Old-Timers' Committee: Nellie Fox (74.7 percent on the 1985 BBWAA ballot), Jim Bunning (74.2 percent in 1988), Orlando Cepeda (73.6 percent in 1994) and Frank Chance (72.5 percent in 1945).


The ace of three World Series winners, Morris had 254 victories and was the winningest pitcher of the 1980s. His 3.90 ERA, however, is higher than that of any Hall of Famer.


___


AP Sports Writers Mike Fitzpatrick, John Marshall and Ben Walker contributed to this report.


Read More..

Bette Midler returning to Broadway as Super Agent Sue Mengers






LOS ANGELES (TheWrap.com) – Bette Midler will return to Broadway for the first time in 30 years to play legendary agent Sue Mengers.


The Divine Miss M will star in John Logan‘s new play “I’ll Eat You Last: A Chat With Sue Mengers.”






For Midler, it is a chance to return to her theatrical roots at a time when her career is experiencing something of a revival. Largely absent from screens for much of the past decade, Midler is starring in the unexpected family comedy hit “Parental Guidance,” which has grossed nearly $ 70 million worldwide since debuting last month.


The chain-smoking, unapologetically brash Mengers was an icon among the New Hollywood set. In a male-dominated time and profession, she became the first female “super agent,” representing the likes of Nick Nolte, Burt Reynolds, Candice Bergen, Ryan O’Neal, Steve McQueen and Barbra Streisand. She rose up the Hollywood ranks despite modest beginnings as a refugee from Nazi Germany. In addition to her professional achievements, her dinner parties were legendary and a ticket to a Mengers’ gathering was considered a sign that a new talent had arrived.


Mengers kept her real age secret, although she was widely believed to be around 80 when she died in 2011 after suffering a series of small strokes. Graydon Carter, her friend and the editor of Vanity Fair, first reported Mengers’ death in a blog post. Carter is one of the producers of “I’ll Eat You Last.”


Logan, who wrote the play, won a Tony Award for “Red,” which examined the life of painter Mark Rothko. He recently wrote the screenplay for the last James Bond movie, “Skyfall,” which has grossed north of $ 1 billion at the worldwide box office.


Logan said he only met Mengers one time at a dinner party, but he was drawn to her wit and sense of sadness.


“At one point I asked her what had changed most about Hollywood since she had arrived,” Logan recalled in a statement. “She didn’t hesitate for a second: ‘Honey, we used to have fun…’ Later in the evening she settled back and lit up a joint. There she was: a joint in one hand and a cigarette in the other. At that moment I knew I had to write the play.”


Tony Award-winning director Joe Mantello (“Wicked,” “Take Me Out”) will stage the play. The show will open April 24 at a Shubert theatre to be announced.


Midler got her start appearing in the Broadway productions of “Fiddler on the Roof” and the rock musical “Salvation” in the 1960s, before becoming a Grammy-winning and Oscar-nominated singer and actress.


In addition to her work in films, such as “The Rose” and “Down and Out in Beverly Hills,” Midler’s stage work includes the Tony Award-winning “Clams on the Half Shell,” the Radio City Music Hall concert “Experience the Divine” and “The Showgirl Must Go On,” which headlined at The Colosseum in Caesars Palace.


Music News Headlines – Yahoo! News





Title Post: Bette Midler returning to Broadway as Super Agent Sue Mengers
Url Post: http://www.news.fluser.com/bette-midler-returning-to-broadway-as-super-agent-sue-mengers/
Link To Post : Bette Midler returning to Broadway as Super Agent Sue Mengers
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment




Read More..

Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported a tantalizing hint that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


Read More..

Dark Horse, Wood start new 'Star Wars' comic


PHILADELPHIA (AP) — There's excitement brewing for fans of the original "Star Wars" trilogy.


Writer Brian Wood and Dark Horse Comics began a new monthly series Wednesday that focuses on Luke Skywalker, Princess Leia Organa, Han Solo and Chewbacca, along with R2D2 and C3P0, as they seek to establish a foothold for the rebellion in the aftermath of the Death Star's destruction.


Wood, whose previous comics include the acclaimed "DMZ" and "Northlanders" at Vertigo and the ongoing "The Massive" at Dark Horse, called the new series about the classic "Star Wars" characters the only such series he could write.


"I know the original trilogy best," he explained, noting that George Lucas' creation has spawned its own universe of expanded characters, books, comics and more.


Disney has already announced plans to revive the "Star Wars" franchise after the events of "Return of the Jedi" in 2015. Milwaukie, Ore.-based Dark Horse has been publishing "Star Wars" comics for more than 20 years.


Woods called the new series — illustrated by Carlos D'Anda — a way to examine the events that transpired between the end of the first film, "Star Wars: A New Hope" and the second film, "The Empire Strikes Back," by detailing the next, furtive steps for the rebellion and the Empire's efforts to stop it from spreading.


"The basic approach is sort of how everybody, including the Empire, is kind of reeling from that battle in various different ways," Wood said. "The rebellion is in need of a home base, Darth Vader is dealing with serious disapproval from the Emperor for having failed to stop the Death Star's destruction — he's actually been demoted!"


Leia has lost her home world. Luke lost his family. Han and Chewie have seen their smuggling business hurt by their association with the rebels.


"Everyone has suffered enormous losses," Wood said.


Wood said the challenge for the series is keeping track of all the story possibilities, given the established mythology of the "Star Wars" universe and the sheer number of characters.


"It's a big cast! The droids, Ben Kenobi is there, all of the Empire, too. It's a very large cast so that's kind of a tricky thing," he said.


And most readers already know what happened to the characters, good and bad.


"It's writing the story knowing what the audience knows but what the characters don't. Obviously, Luke and Leia don't know they're related — I can't ignore that," Wood said.


"It's a very enjoyable challenge walking that line," he said.


___


Matt Moore can be reached at http://www.twitter.com/mattmooreap


___


Online:


Dark Horse: http://bit.ly/RGkqMu


Read More..

Boeing backs its Dreamliner after 3 incidents









Chicago-based Boeing Co. has "extreme confidence" in the Boeing 787 Dreamliner, and the plane is "absolutely 100 percent safe to fly," Mike Sinnett, the chief project engineer for the 787 said during a news conference Wednesday.

The public statements come on the third day in a row that different Boeing 787s have had high-profile problems, including an electrical battery fire on Monday, a fuel leak on Tuesday and a problem with brakes on Wednesday.






"Clearly there are issues," Sinnett said, adding that he won't be happy until the 787 is 100 percent reliable. However, all new planes have such "teething pains," and the 787 problems are similar to incidents experienced when the Boeing 777 went into service, he said.

"This is par for the course for any new airplane program ... just like any new airplane program we work through those issues and move on," he said. "There are no metrics that are screaming at me that we have a problem."

Aviation experts, industry analysts and some Boeing customers have echoed that, saying all new aircraft have such problems for the first year or two and that such glitches don't make flying in a 787 unsafe.

The first 787 Dreamliner was delivered 15 months ago -- more than three years late because of design and production delays -- to a Japanese airline. There are now 50 Dreamliners in service with various airlines around the world.

Chicago-based United Airlines so far has six 787s. Since early November, the airline has temporarily been flying a 787 route between Chicago O'Hare and Houston, as well as on other domestic routes. The Chicago route is scheduled to end March 29, when United will use the 787s on international routes.

LOT Polish Airlines will operate the first regular 787 route out of O'Hare -- to Warsaw -- starting with an inaugural flight scheduled for next week.

The Dreamliner is touted as offering greater passenger comforts and better fuel efficiency than any other airplane in its class, largely due to far more use of light composite materials rather than metals.

However, it has seen its share of problems, including a rash of incidents recently.

Japan's All Nippon Airways said Wednesday it was forced to cancel a 787 Dreamliner flight scheduled to from fly from Yamaguchi prefecture in western Japan to Tokyo due to brake problems. That followed a fuel leak on Tuesday that forced a 787 operated by Japan Airlines to cancel take-off at Boston's Logan International Airport, a day after an electrical fire on another 787 after a JAL flight to Boston from Tokyo.

Last month, the Federal Aviation Administration ordered inspections on 787s for a problem with fuel leaks.

In a news conference Wednesday dominated by technical discussions of the 787's electrical systems and batteries, Sinnett emphasized the "redundancies" or backup protections built into the aircraft's electrical systems. For example, the plane has six power generators but can fly with just one functioning, he said.

The 787 more heavily relies on electrical components than any other aircraft, in an effort to shed the weight of traditional pneumatic systems and improve fuel efficiency, he said.

Overall, the plane is meeting goals for fuel efficiency and passenger comfort, Sinnett said. "We're very, very happy with how the airplane is performing," he said.

Asian customers rallied behind the Boeing, saying such troubles were not uncommon on new planes and confirming they had no plans to scale back or cancel orders for the aircraft, which has a list price of $207 million.

Japan is by far the biggest customer for the Dreamliner to date, with JAL and All Nippon Airways (ANA) operating a total of 24 of the 49 new planes delivered to end-December. The aircraft entered commercial service in November 2011, more than three years behind schedule after a series of production delays. Boeing has sold 848 of the planes.

JAL spokesman Kazunori Kidosaki said the carrier, which operates seven Dreamliners, had no plans to change orders it has placed for another 38 aircraft. ANA, which has 17 Dreamliners flying its colors, will also stick with its orders for another 49, spokesman Etsuya Uchiyama said.

State-owned Air India, which on Monday took delivery of the sixth of the 27 Dreamliners it has ordered, said precautionary measures were already in place and its planes were flying smoothly.

"It's a new plane, and some minor glitches do happen. It's not a cause of concern," said spokesman G. Prasada Rao. There was no immediate suggestion that the 787 Dreamliner, the world's first passenger jet built mainly from carbon-plastic lightweight materials to save fuel, was likely to be grounded as investigators looked into the fire incident.

 Air China, which sees the 787 as a way to expand its international routes, and Hainan Airlines also said they were keeping their orders for 15 and 10 of the planes.

"New airplanes more or less will need adjustments, and currently we have no plans to swap or cancel orders," said an executive at future 787 operator Hainan Airlines, who was not authorized to talk to the media and did not want to be named.

Qatar Airways Chief Executive Akbar Al Baker, who has previously criticized technical problems or delays with Boeing or Airbus jets, said there were no technical problems with the five 787s currently in use by the Gulf carrier. "It doesn't mean we are going to cancel our orders. It's a revolutionary airplane," he said.

gkarp@tribune.com

Reuters contributed

Read More..